منابع مشابه
MAP kinases and histone modification.
Signal transduction pathways alter the gene expression program in response to extracellular or intracellular cues. Mitogen-activated protein kinases (MAPKs) govern numerous cellular processes including cell growth, stress response, apoptosis, and differentiation. In the past decade, MAPKs have been shown to regulate the transcription machinery and associate with chromatin-modifying complexes. M...
متن کاملMAP kinases and cell migration.
Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 ...
متن کاملMAP Kinases and Prostate Cancer
The three major mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK are signal transducers involved in a broad range of cell functions including survival, apoptosis, and cell differentiation. Whereas JNK and p38 have been generally linked to cell death and tumor suppression, ERK plays a prominent role in cell survival and tumor promotion, in response to a broad range of stimuli such as ...
متن کاملMAP Kinases in Meiosis
which the substrate kinase is converted to its active A recent meeting in Spain discussed the most important form will vary as the square of the activity of the upcell divisions in your life: the meioses that produced the stream kinase. Combining two such steps in succession egg and sperm that fused to create you. Most of the produces a cascade in which the activity of MAP kinase talks at the m...
متن کاملMAP kinases in immune responses.
MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular sti...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2012
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjs043